Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cancer stem cell-associated multi-antigen set (CD105, YB-1, SOX2, CDH3, MDM2)
- Molecular classification
- Transcription factor, Cell adhesion molecule, Surface receptor, E3 ubiquitin ligase, RNA-binding protein
01
Overview
This target profile consists of five specific antigens—CD105, YB-1, SOX2, CDH3, and MDM2—that are highly expressed on cancer stem cells (CSCs), particularly in glioblastoma multiforme (GBM) (Source: ClinicalTrials.gov NCT04552808). CD105 (Endoglin) is a TGF-beta co-receptor essential for angiogenesis, while SOX2 is a master transcription factor that maintains the self-renewal capacity of CSCs (Source}
- Other names
- DOC1021 antigensGlioblastoma stem cell antigensCSC-associated antigensCancer stem cell-associated multi-antigen profile
02
Mechanism of action
Active immunotherapy via dendritic cell vaccination to induce a T-cell mediated immune response against cancer stem cells expressing these specific antigens.
03
Biological functions
Stemness maintenanceAngiogenesisCell cycle regulationCell-cell adhesionApoptosis inhibitionImmune response
04
Disease associations
CancerGlioblastoma multiforme
05
Safety considerations
On-target off-tumor toxicity to normal stem cellsAutoimmune reactionsCytokine release syndromeInjection site reactions
06
Interacting drugs
DOC1021
07
Biomarkers
CD105 expressionSOX2 expressionMDM2 expressionYB-1 expressionCDH3 expression
Beyond the preview
Go deeper on Cancer stem cell-associated multi-antigen set (CD105, YB-1, SOX2, CDH3, MDM2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cancer stem cell-associated multi-antigen set (CD105, YB-1, SOX2, CDH3, MDM2).