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Target intelligence / Profile preview
Cancer-testis antigen peptide-HLA-A*03:01 complex (CTA-HLA-A*03:01)
- Target
- CTA-HLA-A*03:01
- Molecular classification
- Peptide-MHC complex, Antigen, MHC Class I molecule
01
Overview
- Other names
- Cancer-testis antigen peptide presented by HLA-A*03:01CTA-pMHC (HLA-A*03:01)Cancer-germline antigen peptide-HLA-A*03:01PRAME peptide-HLA-A*03:01NY-ESO-1 peptide-HLA-A*03:01MAGE-A3 peptide-HLA-A*03:01
02
Mechanism of action
T-cell mediated cytotoxicity via redirected TCR recognition of the pMHC complex
03
Biological functions
Antigen presentationImmune surveillanceT-cell activationCD8+ T-cell mediated cytotoxicity
04
Disease associations
CancerMelanomaSynovial sarcomaOvarian cancerMultiple myelomaNon-small cell lung cancer
05
Safety considerations
Off-target toxicity (cross-reactivity with similar self-peptides)Cytokine release syndrome (CRS)Immune effector cell-associated neurotoxicity syndrome (ICANS)On-target, off-tumor toxicity in healthy tissues with low-level CTA expression
06
Interacting drugs
TCR-engineered T cells (TCR-T)
4 more in the full profile.
07
Biomarkers
HLA-A*03:01 genotypePRAME expression (mRNA/IHC)NY-ESO-1 expression (mRNA/IHC)MAGE-A3 expression (mRNA/IHC)
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