Gosset Molecular Classification
Vascular Structure, Microvasculature
Other Names
Local Circulation, Microcirculation, Capillary Network
Disease Roles
Capillary Bed Overview
A capillary bed is an interwoven network of microscopic blood vessels (capillaries) that connects arterioles to venules, completing the circulatory loop between arteries and veins. These beds are present in virtually all tissues and organs, with their density reflecting the metabolic activity of the tissue they supply. Their primary function is the bidirectional exchange of gases, nutrients, hormones, water, and waste products between blood and surrounding tissues. Regulation of blood flow through capillary beds is achieved locally through autoregulation, metabolic demand, and pericyte activity. Dysfunction can lead to edema, inflammation, and barrier disruption.
Mechanism of Action
N/A
Biological Functions
Exchange of gases (O2/CO2)
Nutrient delivery
Waste removal
Fluid exchange
Regulation of blood flow
Disease Associations
Edema
Inflammation
Ischemia
Hypoxia
Blood-brain barrier disruption
Peripheral neuropathy
Cardiovascular disease
Diabetic microangiopathy
Tumor angiogenesis
Safety Considerations
- Edema formation
- Increased permeability leading to fluid leakage
- Dysfunctional regulation of blood flow
- Compromised barrier function (e.g., blood-brain barrier)
- Uncontrolled angiogenesis in cancer
- Microvascular thrombosis
- Increased vascular permeability
- Risk of hemorrhage
Interacting Drugs
Vasodilators
Vasoconstrictors
Anti-inflammatory drugs
Angiogenesis inhibitors
Anti-edema drugs
Statins
ACE inhibitors
Angiotensin receptor blockers
Associated Biomarkers
| Biomarker |
|---|
| Capillary density |
| Capillary permeability |
| Angiogenic factors (e.g., VEGF) |
| Endothelial cell markers (e.g., CD31) |
| Circulating endothelial cells |
| Biomarkers of inflammation |
| Biomarkers of endothelial dysfunction |