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Gag Polyprotein (None)
- Target
- None
- Molecular classification
- Structural protein, Viral protein, Polyprotein
01
Overview
The Gag polyprotein is indispensable for retroviral replication due to its multifaceted roles in assembling new virus particles at cellular membranes, recruiting/packaging genomes via specific domains/interactions with both viral/cellular factors, mediating release through engagement with ESCRT machinery—and finally undergoing precise cleavage events that transform non-infectious precursors into mature infectious virions. Its structure-function relationships are highly conserved among retroviruses such as HIV.
- Other names
- p55Matrix proteinCapsid proteinNucleocapsid protein
02
Mechanism of action
Target of assembly inhibitors (experimental). Protease inhibitors indirectly impact Gag processing.
03
Biological functions
Viral genome packagingVirion assemblyBudding from host cellsMaturation into infectious particles
04
Disease associations
InfectionHIV infectionAIDS
05
Safety considerations
Drug resistance mutationsPotential for off-target effects with assembly inhibitors
06
Interacting drugs
Protease inhibitors (indirectly)
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