Molecular Classification
Structural Protein
Other Names
Viral Capsid Protein, Capsomere
Disease Roles
Infection

Capsid Protein Overview

The capsid protein is the primary structural protein forming the capsid, which is the protective protein shell of a virus. This shell encloses and safeguards the viral genetic material (DNA or RNA) from environmental hazards. The capsid facilitates attachment to host cells and assists in delivery/uncoating of the viral genome. Capsids are central structurally and functionally, interacting with numerous host factors to evade immune detection or exploit cellular machinery. They are prime targets for antiviral drug development due to their essential role in viral assembly and infectivity.

Mechanism of Action

Disrupts viral assembly/maturation

Biological Functions

Genome protection
Host cell attachment
Genome delivery
Immune evasion
Intracellular trafficking

Disease Associations

Infection

Safety Considerations

  • Potential for off-target effects due to structural similarities with host proteins.
  • Development of drug resistance through mutations in the capsid protein.

Interacting Drugs

Small molecules targeting HIV CA