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Capsid protein (CA)-SP1 Cleavage Site (CA-SP1 Cleavage Site)
- Target
- CA-SP1 Cleavage Site
- Molecular classification
- Protease cleavage site, Viral protein interaction site
01
Overview
The CA-SP1 cleavage site is a critical region within the HIV-1 Gag polyprotein where the viral protease cleaves the capsid protein (CA) from spacer peptide 1 (SP1). This cleavage is essential for virion maturation, leading to the formation of a functional capsid and infectious virus. It is a target for maturation inhibitor drugs like bevirimat, which aim to block this cleavage and prevent proper capsid assembly.
- Other names
- CA-SP1 junctionCapsid-Spacer Peptide 1 Cleavage SiteHIV-1 Gag CA-SP1 Cleavage Site
02
Mechanism of action
Inhibition of HIV-1 protease-mediated cleavage at the CA-SP1 junction, preventing proper capsid assembly and virion maturation.
03
Biological functions
HIV-1 Gag polyprotein processingVirion maturationCapsid assemblyInfectivity
04
Disease associations
InfectionHIV-1 infectionAIDS
05
Safety considerations
Resistance mutations can emerge, reducing drug efficacy.Potential for off-target effects due to protease inhibition.
06
Interacting drugs
Bevirimat
1 more in the full profile.
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