Target intelligence / Profile preview

Capsid protein (HIV) (CA)

Target: CA
Molecular classification: Viral protein, Structural protein

Overview

The HIV capsid protein, often referred to as CA or p24, is a critical structural component of the human immunodeficiency virus (HIV) virion. It plays essential roles in both the early and late stages of the viral life cycle, facilitating viral genome protection, trafficking within host cells, and interactions with host factors necessary for successful infection.

Other names: p24

Mechanism of action

Disruption of capsid assembly, uncoating, or nuclear import

Biological functions

Genome protectionTraffickingNuclear importViral assemblyViral maturation

Disease associations

Infection

Safety considerations

Resistance mutationsGenetic diversity impacting inhibitor susceptibility

Biomarkers

p24 antigen

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