Molecular Classification
Enzyme, Hydrolase
Other Names
Amylase, Salivary Amylase, Pancreatic Amylase, Disaccharidases, Maltase, Sucrase, Lactase, Isomaltase, Trehalase
Disease Roles
Lactose intoleranceSucrase-isomaltase deficiencyMaldigestion

Carbohydrate-Digesting Enzymes Overview

Carbohydrate-digesting enzymes are a group of digestive enzymes responsible for breaking down complex carbohydrates (polysaccharides and disaccharides) into absorbable monosaccharides (such as glucose, fructose, and galactose). These enzymes act at various stages of the digestive tract, starting in the mouth and continuing through the small intestine. Key enzymes include salivary amylase, pancreatic amylase, and brush border disaccharidases like maltase, sucrase, lactase, isomaltase and trehalase. They hydrolyze dietary carbohydrates so that they can be absorbed across intestinal epithelial cells. Deficiencies or inhibition of these enzymes can result in gastrointestinal symptoms due to maldigestion/malabsorption.

Mechanism of Action

Acarbose inhibits some brush border disaccharidases, slowing carbohydrate absorption.

Biological Functions

Carbohydrate digestion
Hydrolysis of glycosidic bonds
Energy extraction from carbohydrates

Disease Associations

Lactose intolerance
Sucrase-isomaltase deficiency
Maldigestion
Malabsorption
Gastrointestinal disorders

Safety Considerations

  • Gastrointestinal side effects (gas, bloating, diarrhea) due to undigested carbohydrates reaching the colon.
  • Potential for drug interactions affecting carbohydrate metabolism.

Interacting Drugs

Acarbose