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Target intelligence / Profile preview
Carbonic Anhydrase 12 (CA12)
- Target
- CA12
- Molecular classification
- Enzyme, Metalloprotein, Carbonic Anhydrase, Membrane-bound enzyme
01
Overview
Carbonic anhydrase 12 (CA12) is a membrane-associated zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide to bicarbonate and protons. It plays a crucial role in pH regulation, ion transport, and fluid secretion in various tissues. Overexpression is associated with certain cancers, while loss-of-function mutations can lead to electrolyte imbalances and impaired fluid secretion.
- Other names
- CAXIICA-XIICarbonate Dehydratase XIICarbonic DehydrataseTumor Antigen HOM-RCC-3.1.3Car12
02
Mechanism of action
Carbonic anhydrase inhibitors block the active site of the enzyme, preventing the hydration of carbon dioxide and subsequent production of bicarbonate and protons. This can affect pH regulation and ion transport.
03
Biological functions
Acid-base balanceChloride ion homeostasispH regulationFluid secretionElectrolyte secretionRespirationCalcification
04
Disease associations
Isolated HyperchlorhidrosisCystic Fibrosis-like SyndromePancreatitisXerostomiaClear Cell Renal CarcinomaCancer
05
Safety considerations
Electrolyte imbalancePotential for off-target effects with carbonic anhydrase inhibitors affecting other isozymes.
06
Interacting drugs
Acetazolamide
07
Biomarkers
CA12 overexpression in tumor tissue (e.g., clear cell renal carcinoma)
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