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Carbonic anhydrase 5A, mitochondrial (None)
- Target
- None
- Molecular classification
- Enzyme, Metalloprotein
01
Overview
Carbonic anhydrase 5A, mitochondrial (CA5A) is a zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide to bicarbonate within mitochondria. It plays a crucial role in providing bicarbonate for carbamoyl phosphate synthetase I (urea cycle) and pyruvate carboxylase (gluconeogenesis), among other enzymes. CA5A is primarily expressed in the liver, and its deficiency leads to hyperammonaemia due to impaired ammonia detoxification. Treatment includes carglumic acid administration to support the urea cycle.
- Other names
- CA5CA5ADCAVCAVAGS1-21A4.1carbonic anhydrase VA/VA-mitochondrial
02
Mechanism of action
Carglumic acid enhances the activity of carbamoyl phosphate synthetase I, bypassing the need for CA5A-produced bicarbonate in the urea cycle and thus reducing hyperammonaemia.
03
Biological functions
CatalysisCarbon dioxide hydrationBicarbonate productionUreagenesis supportGluconeogenesis supportAcid-base balance
04
Disease associations
Carbonic anhydrase VA deficiencyHyperammonaemia
05
Safety considerations
Potential for hyperammonaemia recurrence despite treatmentVaried efficacy across patients due to residual enzyme activityNeed for careful monitoring to prevent metabolic decompensation
06
Interacting drugs
Carglumic acid
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