Carbonic anhydrase 5B, mitochondrial (CA5B)

Carbonic anhydrase 5B, mitochondrial (CA5B), is a mitochondrial enzyme that catalyzes the reversible conversion of carbon dioxide to bicarbonate, using a zinc ion as a cofactor[1][2][3][5][9]. CA5B is distributed across a wide range of tissues including brain, liver, kidney, muscle, and pancreas, and plays roles in intermediary metabolism and maintenance of acid-base balance[1][2]. It is a member of the carbonic anhydrase family, which comprises zinc metalloenzymes involved in various physiological processes. Inhibition can disrupt key metabolic pathways and has been linked to altered mitochondrial function, with clinical interest in certain metabolic disorders[1][3]. Multiple drugs, including some thiazide diuretics and anticonvulsants, have inhibitory activity against CA5B[3].

Other names

CA-VBCarbonic anhydrase VBCarbonate dehydratase VBCAH5B

Inhibition of mitochondrial carbonic anhydrase activity (block reversible conversion of CO₂ to bicarbonate, impacting intermediary metabolism and acid-base balance)[3][5]