Molecular Classification
Enzyme, Lyase, Zinc metalloenzyme
Disease Roles
GlaucomaEdemaRenal abnormalities related to bicarbonate transport

Carbonic Anhydrase IV Overview

Carbonic anhydrase type IV (CA IV) is a membrane-associated enzyme that catalyzes the reversible hydration of carbon dioxide. It plays key roles in pH regulation, respiration, and electrolyte secretion, particularly in pulmonary capillaries and renal tubules. Its structure features unique disulfide bonds and loops, making it a target for specific inhibitors used in the treatment of glaucoma and edema.

Mechanism of Action

Inhibition of carbonic anhydrase activity, modulating fluid secretion or absorption processes

Biological Functions

Regulation of intracellular and extracellular pH
Respiration
Renal tubular acidification
Bone resorption
Formation of aqueous humor
Formation of cerebrospinal fluid
Saliva production
Gastric acid production
CO2/bicarbonate transport

Disease Associations

Glaucoma
Edema
Renal abnormalities related to bicarbonate transport

Safety Considerations

  • Inhibition can affect pH regulation mechanisms throughout various tissues

Interacting Drugs

Acetazolamide
Topiramate
Brinzolamide