Molecular Classification
Enzyme, Carbonic Anhydrase, Transmembrane glycoprotein
Other Names
CA9, MN/G250
Disease Roles
CancerTumor hypoxia

Carbonic Anhydrase IX Overview

Carbonic anhydrase IX (CA IX) is a transmembrane glycoprotein enzyme that catalyzes the reversible hydration of carbon dioxide. It is minimally expressed in normal tissues but highly upregulated in various solid tumors, particularly under hypoxic conditions. CA IX plays a crucial role in pH regulation and cell adhesion within the tumor microenvironment, promoting tumor growth and metastasis. It serves as a prognostic marker and a therapeutic target for cancer.

Mechanism of Action

Inhibition of carbonic anhydrase activity, disruption of pH regulation in tumor microenvironment

Biological Functions

pH regulation
CO2 hydration
Acid-base balance
Cell adhesion control

Disease Associations

Cancer
Tumor hypoxia

Safety Considerations

  • Potential for off-target effects (though limited normal tissue expression)
  • Ectodomain shedding may affect drug efficacy

Interacting Drugs

Sulfonamides
Monoclonal antibodies targeting CA IX

Associated Biomarkers

Biomarker
CA IX expression in tumors (prognostic marker)
Tumor hypoxia marker