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Target intelligence / Profile preview
Carbonic Anhydrase IX (CA IX)
- Target
- CA IX
- Molecular classification
- Enzyme, Carbonic Anhydrase, Transmembrane glycoprotein
01
Overview
Carbonic anhydrase IX (CA IX) is a transmembrane glycoprotein enzyme that catalyzes the reversible hydration of carbon dioxide. It is minimally expressed in normal tissues but highly upregulated in various solid tumors, particularly under hypoxic conditions. CA IX plays a crucial role in pH regulation and cell adhesion within the tumor microenvironment, promoting tumor growth and metastasis. It serves as a prognostic marker and a therapeutic target for cancer.
- Other names
- CA9MN/G250
02
Mechanism of action
Inhibition of carbonic anhydrase activity, disruption of pH regulation in tumor microenvironment
03
Biological functions
pH regulationCO2 hydrationAcid-base balanceCell adhesion control
04
Disease associations
CancerTumor hypoxia
05
Safety considerations
Potential for off-target effects (though limited normal tissue expression)Ectodomain shedding may affect drug efficacy
06
Interacting drugs
Sulfonamides
1 more in the full profile.
07
Biomarkers
CA IX expression in tumors (prognostic marker)Tumor hypoxia marker
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