Carboxypeptidase E (CPE)

Carboxypeptidase E (CPE), also known as carboxypeptidase H or neurotrophic factor-α1 (CPE-NFα1), is a zinc-dependent metallocarboxypeptidase primarily involved in the processing and maturation of peptide hormones and neuropeptides. It functions by cleaving basic amino acids from the C-terminal end of peptide precursors, thereby generating their active forms. Beyond hormone processing, CPE plays critical roles in metabolic processes including glucose homeostasis, bone remodeling, fertility regulation, stress response modulation, learning/memory formation, mood/emotional responses. Dysfunctions are linked with obesity, diabetes mellitus type II, infertility, learning disabilities/cognitive impairment, and neurodegenerative diseases.

Other names

Carboxypeptidase HNeurotrophic factor-α1CPE-NFα1

Cleaves C-terminal basic amino acids from peptide precursors