Target intelligence / Profile preview

Cardiomyocyte (Cell Replacement)

Molecular classification: Cell, Muscle Cell

Overview

Cardiomyocytes are the contractile cells of the heart. In cell replacement therapy, exogenous or engineered cardiomyocytes (often from pluripotent stem cells) are used to replace lost/damaged cells after myocardial injury, aiming to restore contractile tissue and cardiac function through remuscularization and paracrine effects.

Other names: PSC-CMsPluripotent stem cell-derived cardiomyocytesiPSC-CMsInduced pluripotent stem cell-derived cardiomyocytesESC-CMsEmbryonic stem cell-derived cardiomyocytes

Mechanism of action

Remuscularization of damaged myocardium; Paracrine signaling to promote endogenous repair

Biological functions

Cardiac contractionElectromechanical couplingSecretion of paracrine factors

Disease associations

Myocardial infarctionHeart failureCardiovascular disease

Safety considerations

ArrhythmiasImmune rejectionTumor formation from undifferentiated cellsEnsuring long-term survival and functional integration

Biomarkers

Cardiac troponins (TnT/I)α-actininMyosin heavy chain isoformsNT-proBNPLVEF (Left Ventricular Ejection Fraction)

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