Target intelligence / Profile preview

Catechol-O-methyltransferase (COMT)

Target: COMT
Molecular classification: Enzyme

Overview

Catechol-O-methyltransferase (COMT) is an enzyme that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to catecholamines and other catecholic substrates, leading to their inactivation. It plays a crucial role in the metabolism of neurotransmitters such as dopamine, epinephrine, and norepinephrine, as well as catecholestrogens and certain drugs.

Mechanism of action

Inhibition of COMT

Biological functions

Neurotransmitter MetabolismHormone Metabolism

Disease associations

Parkinson's DiseaseCentral nervous system disordersCancer

Interacting drugs

Entacapone

2 more in the full profile.

Biomarkers

rs4680 Val158Met polymorphism

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