Gosset Molecular Classification
Enzyme, Methyltransferase
Disease Roles
Catechol-O-methyltransferase Overview
Catechol-O-methyltransferase (COMT) is a key enzyme involved in the metabolism of catecholamines, including neurotransmitters such as dopamine, epinephrine (adrenaline), and norepinephrine (noradrenaline). It catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to catecholic substrates, deactivating them. COMT plays a major role in regulating dopamine levels, particularly in the prefrontal cortex, affecting cognitive functions and is implicated in various neuropsychiatric disorders. Genetic polymorphisms, such as Val158Met, influence its activity and are linked to disease risk and drug response.
Mechanism of Action
Inhibition of COMT activity, preventing the breakdown of catecholamines and L-DOPA
Biological Functions
Catecholamine metabolism
Neurotransmitter regulation
O-methylation
Disease Associations
Neuropsychiatric disorders
Schizophrenia
Mood disorders
Depression
Bipolar disorder
Obsessive-compulsive disorder
ADHD
Substance abuse disorders
Parkinson's disease
Safety Considerations
- Individual responses to drugs metabolized by COMT
- Side effect profiles of dopaminergic agents
- Variations in efficacy of treatments involving dopaminergic agents or nicotine replacement therapy
Interacting Drugs
Entacapone
L-DOPA
Associated Biomarkers
| Biomarker |
|---|
| Val158Met polymorphism (rs4680) |