Gosset CC-chemokine ligand 2 Overview
CC-chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein-1 (MCP-1), is a small cytokine belonging to the CC chemokine family. It plays a central role in immune cell recruitment, particularly of monocytes, and is involved in various physiological and pathological processes. CCL2 primarily functions to recruit immune cells—especially monocytes—from the bloodstream into tissues at sites of inflammation or injury. It also influences differentiation pathways and is involved in angiogenesis. The CCL2/CCR2 axis represents an important therapeutic target due to its involvement in chronic inflammatory diseases, cancer metastasis/tumor microenvironment modulation, bone metabolism disorders, pregnancy complications, cardiovascular pathology, etc.
Mechanism of Action
Inhibition of CCL2/CCR2 axis
Biological Functions
Disease Associations
Safety Considerations
- Potential for off-target effects due to chemokine redundancy
- Complex role in immune regulation; inhibition may have unintended consequences