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Target intelligence / Profile preview
CC Chemokine Ligand 2 (CCL2)
- Target
- CCL2
- Molecular classification
- Chemokine, CC chemokine
01
Overview
CCL2, also known as monocyte chemoattractant protein-1 (MCP-1), is a proinflammatory chemokine that mediates the recruitment of monocytes and other immune cells to sites of inflammation. It plays a significant role in tumor progression, atherosclerosis, and other chronic inflammatory conditions, making it a relevant therapeutic target.
- Other names
- MCP-1Monocyte chemoattractant protein-1
02
Mechanism of action
Inhibition of CCL2 binding to CCR2, preventing downstream signaling and cell migration
03
Biological functions
ChemotaxisImmune cell recruitmentImmune modulationAngiogenesis
04
Disease associations
CancerAtherosclerosisChronic inflammationPain modulation
05
Safety considerations
Potential for immunosuppressionOff-target effects due to chemokine redundancyVariability in clinical efficacy
06
Interacting drugs
Small molecule CCR2 inhibitors
2 more in the full profile.
07
Biomarkers
CCL2 expression levels in tumor microenvironmentCCR2 expression levels on immune cells
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