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Target intelligence / Profile preview
CD13 Antigen (Aminopeptidase N) (APN)
- Target
- APN
- Molecular classification
- Type II transmembrane glycoprotein, Metalloprotease, Ectopeptidase
01
Overview
CD13 Antigen, also known as Aminopeptidase N (APN), is a type II transmembrane glycoprotein and zinc-dependent ectopeptidase expressed on myeloid lineage hematopoietic cells and various nonhematopoietic tissues. It plays a role in peptide metabolism, antigen processing, cell adhesion, and angiogenesis. It is involved in infection by human coronavirus HCoV-229E and cytomegalovirus. CD13 is a marker for certain leukemias and is associated with poor prognosis in carcinomas. Its soluble form is implicated in angiogenesis and inflammation, making it a potential therapeutic target.
- Other names
- Aminopeptidase NPEPNANPEPgp150LAP1
02
Mechanism of action
Inhibition of enzymatic activity, modulation of cell adhesion and migration, targeting for drug delivery
03
Biological functions
Peptide metabolismModulation of bioactive peptidesAntigen processing and presentationCell growth and differentiation controlPhagocytosisBactericidal activityTumoricidal activityCell adhesionRegulation of cell motility/migration/invasionAngiogenesis
04
Disease associations
Acute myeloid leukemiaChronic myeloid leukemiaCancer progression and metastasisInflammatory diseasesInfection
05
Safety considerations
Potential for off-target effects due to broad tissue expressionRole in angiogenesis could complicate anti-cancer therapiesModulation of immune responses requires careful consideration
06
Biomarkers
Leukemia markerPrognostic indicator in carcinomas
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