CD151 mRNA 3' untranslated region (CD151 3' UTR)

The CD151 mRNA 3' untranslated region (3' UTR) is a critical regulatory segment of the CD151 transcript that governs the stability and translation of the CD151 protein, a member of the tetraspanin superfamily [3, 6]. This region contains multiple cis-regulatory elements and binding sites for microRNAs (miRNAs), such as miR-22 and miR-637, which post-transcriptionally repress CD151 expression by inducing mRNA degradation or inhibiting translation [2, 5, 11]. CD151 itself is a key mediator of cellular processes including migration, invasion, and adhesion, primarily through its robust association with laminin-binding integrins like α3β1 and α6β4 [3, 12]. In various solid malignancies, such as breast, prostate, and lung cancers, CD151 is frequently overexpressed and correlates with advanced disease stages, metastasis, and resistance to anti-cancer therapies [6, 8, 10]. Consequently, the CD151 3' UTR is an attractive therapeutic target for RNA-based interventions, including antisense oligonucleotides (ASOs) and miRNA mimics, designed to silence CD151 and suppress its oncogenic activity [2, 7, 13]. Beyond oncology, the regulation of CD151 mRNA levels has been implicated in the therapeutic mechanisms of mood stabilizers like lithium and valproate in the treatment of bipolar disorder [1].

Other names

CD151 3' untranslated regionTSPAN24 mRNA 3' UTRPETA-3 mRNA 3' UTRSFA-1 mRNA 3' UTRGP-27 mRNA 3' UTR

miRNA-mediated translational repression and mRNA degradation; antisense oligonucleotide-mediated gene silencing through RNase H recruitment or steric hindrance of regulatory elements.