CD16 Fc Receptor (CD16)

CD16 (FcγRIII) is an Fc receptor that binds to the Fc portion of IgG antibodies, playing a crucial role in antibody-dependent cellular cytotoxicity (ADCC) and other immune functions. It exists in two main isoforms: CD16A, a transmembrane form expressed on NK cells, macrophages, and some neutrophils; and CD16B, a GPI-linked form primarily found on neutrophils. CD16 engagement triggers downstream signaling pathways leading to degranulation, cytokine release, and phagocytosis, making it an important target for therapeutic monoclonal antibodies designed to enhance ADCC against cancer or infected cells. Its expression is dynamically regulated, and variations in its function can influence the efficacy of antibody-based therapies.

Other names

FcγRIIIFc gamma receptor IIICD16A (FcγRIIIA)CD16B (FcγRIIIB)FCGR3AFCGR3B

Mediates antibody-dependent cellular cytotoxicity (ADCC) by binding to the Fc region of IgG antibodies and triggering downstream signaling cascades in immune cells, such as NK cells, leading to target cell lysis.