Gosset Molecular Classification
B lymphocyte, Immune cell
Disease Roles
CD20-positive B cell Overview
CD20-positive B cells are a subset of B lymphocytes characterized by the expression of the CD20 surface antigen. They are involved in antibody production, antigen presentation, cytokine secretion, and immune regulation. Aberrant populations or functions of CD20-positive B cells are associated with autoimmune diseases and hematologic malignancies, making them therapeutic targets for monoclonal antibodies like rituximab.
Mechanism of Action
Antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), direct apoptosis induction via anti-CD20 antibody binding.
Biological Functions
Antibody production
Antigen presentation
Cytokine secretion
Immune regulation
Maintenance of resting state in mature B lymphocytes
Receptor organization
Disease Associations
Autoimmunity
Hematologic malignancy
Safety Considerations
- Infusion reactions
- Tumor lysis syndrome
- Progressive multifocal leukoencephalopathy (PML)
- Increased risk of infection
Interacting Drugs
Rituximab
Associated Biomarkers
| Biomarker |
|---|
| CD20 expression level for patient selection |
| B cell counts for monitoring depletion therapy |