Gosset Molecular Classification
Receptor, Type I transmembrane protein
Other Names
IL-2Rα, Cluster of Differentiation 25, Tac antigen, P55, IL2RA
Disease Roles
Interleukin-2 Receptor Alpha Subunit Overview
The Interleukin-2 receptor alpha subunit (CD25) is a transmembrane protein that forms part of the IL-2 receptor complex. While it does not directly signal, it regulates IL-2 binding and affinity, playing a crucial role in T cell activation, regulatory T cell function, and immune homeostasis. CD25 is a therapeutic target in autoimmunity and cancer, and soluble CD25 serves as a biomarker for immune activation and disease activity.
Mechanism of Action
Regulates IL-2 binding affinity and presentation to signaling subunits; antibody-based therapies block CD25 function or induce cell death
Biological Functions
Signal transduction
Immune response
Cell proliferation
Regulation of T cell function
Maintenance of regulatory T cells
Cytokine signaling
Disease Associations
Autoimmune disorders
Cancer
Infection
Inflammation
Immunodeficiency
Safety Considerations
- Potential for immune dysregulation
- Off-target effects of antibody therapies
- Risk of cytokine release syndrome
Interacting Drugs
Low-dose recombinant human IL-2
Antibody-based therapies targeting CD25
Associated Biomarkers
| Biomarker |
|---|
| Soluble CD25 (sIL-2Rα/sCD25) |
| CD25 expression level on T cells |