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Target intelligence / Profile preview
CD3 Antigen on T Cells (CD3)
- Target
- CD3
- Molecular classification
- Receptor, Immunoglobulin superfamily, Co-receptor
01
Overview
CD3, or cluster of differentiation 3, is a multimeric protein complex and a defining co-receptor of the T cell lineage. It is essential for T cell activation and signal transduction. The CD3 complex is noncovalently associated with the T cell receptor (TCR) and plays a central role in transmitting signals from antigen recognition into intracellular responses.
02
Mechanism of action
Anti-CD3 antibodies deplete circulating mature lymphocytes or redirect cytotoxic lymphocytes to cancer cells. Modulation through anti-CD3 can induce either immune activation or tolerance.
03
Biological functions
Signal transductionT cell activationImmune responseT cell development
04
Disease associations
CancerAutoimmune diseasesTransplant rejectionImmunodeficiency
05
Safety considerations
Immune modulationCytokine release syndrome
06
Interacting drugs
OKT3/muromonab-CD3
1 more in the full profile.
07
Biomarkers
CD3 expression levels in peripheral blood or tissue-infiltrating lymphocytes
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