Gosset Molecular Classification
Receptor, Immunoglobulin superfamily, Co-receptor
Disease Roles
CD3 Antigen on T Cells Overview
CD3, or cluster of differentiation 3, is a multimeric protein complex and a defining co-receptor of the T cell lineage. It is essential for T cell activation and signal transduction. The CD3 complex is noncovalently associated with the T cell receptor (TCR) and plays a central role in transmitting signals from antigen recognition into intracellular responses.
Mechanism of Action
Anti-CD3 antibodies deplete circulating mature lymphocytes or redirect cytotoxic lymphocytes to cancer cells. Modulation through anti-CD3 can induce either immune activation or tolerance.
Biological Functions
Signal transduction
T cell activation
Immune response
T cell development
Disease Associations
Cancer
Autoimmune diseases
Transplant rejection
Immunodeficiency
Safety Considerations
- Immune modulation
- Cytokine release syndrome
Interacting Drugs
OKT3/muromonab-CD3
T-cell engagers
Associated Biomarkers
| Biomarker |
|---|
| CD3 expression levels in peripheral blood or tissue-infiltrating lymphocytes |