Molecular Classification
Scavenger Receptor, Class B Scavenger Receptor, Transmembrane Glycoprotein
Other Names
Oxidized LDL Receptor, Fatty Acid Translocase, Thrombospondin Receptor
Disease Roles
AtherosclerosisCardiovascular DiseaseCancer Progression

CD36 Molecule Overview

CD36, also known as the oxidized LDL receptor, is a multifunctional membrane glycoprotein and a member of the class B scavenger receptor family. It is widely expressed on various cell types and plays critical roles in lipid metabolism, immunity, angiogenesis regulation, and disease pathogenesis. CD36 binds to a diverse array of ligands including oxidized low-density lipoprotein (oxLDL), long-chain fatty acids and proteins with thrombospondin structural homology repeat (TSR) domains. Its function in oxLDL uptake by macrophages contributes significantly to foam cell formation in atherosclerotic lesions. It also regulates angiogenesis, fatty acid transport, and immune responses.

Mechanism of Action

Blocking CD36 mediated functions reduces foam cell formation and plaque progression in atherosclerosis; Inhibiting CD36 suppresses tumor growth and metastasis by targeting metabolic reprogramming and stemness features

Biological Functions

Lipid Uptake
Scavenging
Immune Response Modulation
Angiogenesis Regulation
Fatty Acid Transport
Cell Adhesion

Disease Associations

Atherosclerosis
Cardiovascular Disease
Cancer Progression
Metabolic Syndrome
Inflammation
Obesity
Diabetes

Safety Considerations

  • Potential for off-target effects due to broad expression
  • Complexity of its diverse functions may lead to unforeseen consequences
  • Immune suppression

Interacting Drugs

Blocking Antibodies
Small Molecule Inhibitors
Thrombospondin-1
Thrombospondin-2

Associated Biomarkers

Biomarker
CD36 Expression Levels