CD36 Molecule (CD36)

CD36, also known as the oxidized LDL receptor, is a multifunctional membrane glycoprotein and a member of the class B scavenger receptor family. It is widely expressed on various cell types and plays critical roles in lipid metabolism, immunity, angiogenesis regulation, and disease pathogenesis. CD36 binds to a diverse array of ligands including oxidized low-density lipoprotein (oxLDL), long-chain fatty acids and proteins with thrombospondin structural homology repeat (TSR) domains. Its function in oxLDL uptake by macrophages contributes significantly to foam cell formation in atherosclerotic lesions. It also regulates angiogenesis, fatty acid transport, and immune responses.

Other names

Oxidized LDL ReceptorFatty Acid TranslocaseThrombospondin Receptor

Blocking CD36 mediated functions reduces foam cell formation and plaque progression in atherosclerosis; Inhibiting CD36 suppresses tumor growth and metastasis by targeting metabolic reprogramming and stemness features