Gosset Molecular Classification
Tetraspanin, Transmembrane 4 superfamily, Cell surface glycoprotein
Other Names
Tetraspanin 26, TSPAN26, CD37 antigen
Disease Roles
CD37 Overview
CD37 is a cell surface glycoprotein and a member of the tetraspanin (transmembrane 4 superfamily) protein family. It is highly expressed on mature B cells and plays a key role in immune regulation, including cell development, activation, growth, motility, and humoral/cellular immune responses. CD37 forms complexes with integrins and other tetraspanins to create tetraspanin-enriched microdomains (TEMs). It has been implicated in diseases such as Mantle Cell Lymphoma and Diffuse Large B-Cell Lymphoma, where patients lacking CD37 have worse clinical outcomes.
Mechanism of Action
Biological Functions
Immune regulation
Cell development
Cell activation
Cell growth
Cell motility
Humoral immune response
Cellular immune response
Signal transduction
Integrin complex formation
Tetraspanin-enriched microdomain (TEM) formation
Macrophage dectin-1 stabilization
T-cell receptor signaling inhibition
Dendritic cell migration/adhesion
Neutrophil migration/adhesion
Disease Associations
Mantle Cell Lymphoma
Diffuse Large B-Cell Lymphoma
Safety Considerations
No safety concerns listed
Associated Biomarkers
| Biomarker |
|---|
| CD37 expression levels in lymphoma patients (prognostic) |