Target intelligence / Profile preview

CD37

Molecular classification: Tetraspanin, Transmembrane 4 superfamily, Cell surface glycoprotein

Overview

CD37 is a cell surface glycoprotein and a member of the tetraspanin (transmembrane 4 superfamily) protein family. It is highly expressed on mature B cells and plays a key role in immune regulation, including cell development, activation, growth, motility, and humoral/cellular immune responses. CD37 forms complexes with integrins and other tetraspanins to create tetraspanin-enriched microdomains (TEMs). It has been implicated in diseases such as Mantle Cell Lymphoma and Diffuse Large B-Cell Lymphoma, where patients lacking CD37 have worse clinical outcomes.

Other names: Tetraspanin 26TSPAN26CD37 antigen

Biological functions

Immune regulationCell developmentCell activationCell growthCell motilityHumoral immune responseCellular immune responseSignal transductionIntegrin complex formationTetraspanin-enriched microdomain (TEM) formationMacrophage dectin-1 stabilizationT-cell receptor signaling inhibitionDendritic cell migration/adhesionNeutrophil migration/adhesion

Disease associations

Mantle Cell LymphomaDiffuse Large B-Cell Lymphoma

Biomarkers

CD37 expression levels in lymphoma patients (prognostic)

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