CD4+ T-cell receptor recognizing Pru p 3-derived peptides (Pru p 3-specific TCR)

The CD4+ T-cell receptor recognizing Pru p 3-derived peptides is a primary mediator of the immune response in peach allergy, particularly in the Mediterranean region where Pru p 3 is the dominant allergen (PMID: 10474031). Pru p 3 is a non-specific lipid transfer protein (nsLTP) that is highly resistant to pepsin digestion, allowing it to act as a potent sensitizer via the gastrointestinal tract (PMID: 15596312). These T-cell receptors (TCRs) recognize specific immunodominant epitopes, such as the Pru p 3 11-25 and 57-71 sequences, presented by MHC class II molecules (PMID: 17302591). Activation of these CD4+ T cells leads to a Th2-biased cytokine environment (IL-4, IL-5, IL-13), which promotes B-cell isotype switching to IgE (PMID: 22404458). Therapeutic strategies targeting these TCRs include peptide-based immunotherapy (PIT) and sublingual immunotherapy (SLIT), which aim to induce T-cell anergy or promote the expansion of Pru p 3-specific regulatory T cells (Tregs) to restore clinical tolerance (PMID: 25173577). Understanding the TCR repertoire and epitope specificity is essential for developing safe and effective desensitization treatments for patients at risk of severe systemic reactions (PMID: 24117904).

Other names

Pru p 3-specific T-cell receptorPeach allergen-specific T-cell receptornsLTP-specific T-cell receptor

Induction of immunological tolerance through T-cell anergy, deletion, or the differentiation of regulatory T cells (Tregs) that suppress Th2-mediated allergic inflammation (PMID: 25173577).