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Target intelligence / Profile preview
CD4 Binding Site (HIV Envelope) (CD4 Binding Site)
- Target
- CD4 Binding Site
- Molecular classification
- Viral protein domain, Envelope glycoprotein
01
Overview
The CD4 binding site is a highly conserved region on the HIV envelope glycoprotein gp120. This site is essential for the virus’s ability to attach to and enter host cells, specifically by binding to the CD4 receptor found primarily on helper T-cells. The interaction between gp120 and CD4 initiates a cascade of conformational changes in both gp120 and its partner subunit, gp41, ultimately leading to fusion of the viral membrane with the host cell membrane and entry of viral genetic material. Targeting this site is a major approach for developing neutralizing antibodies and small-molecule inhibitors to block viral entry.
- Other names
- gp120 CD4 binding siteHIV Env CD4 binding siteCD4bs
02
Mechanism of action
Blocks viral entry by preventing gp120-CD4 interaction
03
Biological functions
Viral entryReceptor bindingMembrane fusion
04
Disease associations
InfectionHIV infectionAIDS
05
Safety considerations
Immune evasion due to high variability in surrounding regionsChallenges in eliciting broadly neutralizing antibodies
06
Interacting drugs
Entry inhibitors (small molecules)
1 more in the full profile.
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