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Target intelligence / Profile preview
CD4 Binding Site on Envelope Glycoprotein gp160 (HIV) (CD4 Binding Site (gp160))
- Target
- CD4 Binding Site (gp160)
- Molecular classification
- Viral protein domain, Glycoprotein domain
01
Overview
The CD4 binding site on HIV's envelope glycoprotein precursor (gp160)—specifically localized within its mature surface subunit, gp120—is indispensable for virus attachment to host immune cells via direct interaction with their CD4 receptors. Its structural conservation makes it both an Achilles’ heel exploited by neutralizing antibodies/vaccine strategies and a focal point in understanding mechanisms underlying viral entry/fusion dynamics.
- Other names
- gp120 CD4 binding siteHIV envelope CD4 binding siteCD4bs on gp120Env CD4 binding site
02
Mechanism of action
Inhibition of viral attachment by blocking the interaction between gp120 and the CD4 receptor on host cells
03
Biological functions
Viral attachment to host cellInitiation of viral entryReceptor binding
04
Disease associations
HIV infectionAIDS pathogenesis
05
Safety considerations
Antibody resistance due to viral mutationGlycosylation site variability affecting antibody efficacy
06
Interacting drugs
b12 (antibody)
3 more in the full profile.
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