CD4-positive T Lymphocyte (CD4+ T cell)

CD4-positive T Lymphocyte Overview

CD4-positive T lymphocytes, also known as CD4+ T cells or helper T cells, are a subset of lymphocytes that play a central role in the adaptive immune system. They express the surface glycoprotein CD4 and are essential for coordinating immune responses by activating and regulating other immune cell types. They are critical in diseases such as HIV/AIDS, where they are targeted by the virus, leading to immunodeficiency.

Mechanism of Action

CD4+ T cells are targeted by HIV for entry and replication, leading to their depletion. Immunosuppressants can broadly affect T cell activity, including CD4+ T cells. Other therapies might target specific CD4+ T cell functions or subtypes through cytokine modulation or co-stimulatory molecule blockade.

Biological Functions

Safety Considerations

Interacting Drugs

Associated Biomarkers