Gosset Molecular Classification
Receptor, Cell surface glycoprotein
Other Names
T-helper cell, CD4+ T cell, Helper T cell
Disease Roles
CD4 T Lymphocyte Overview
CD4 is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. It acts as a receptor and co-receptor in T cell signaling and plays a crucial role in immune responses. HIV exploits CD4 as its primary entry receptor to infect and destroy these cells, leading to immunodeficiency.
Mechanism of Action
Post-attachment inhibitor of HIV entry by blocking the interaction between virus-bound CD4 and chemokine co-receptors (CCR5/CXCR4).
Biological Functions
Immune response
T cell activation
Antigen recognition
Co-receptor for T cell receptor signaling
Disease Associations
HIV infection
Immunodeficiency
Autoimmune diseases
Safety Considerations
- Potential for immune suppression
- Risk of infusion-related reactions (for monoclonal antibody therapies like Ibalizumab)
- Need for careful monitoring of immune function
Interacting Drugs
Ibalizumab
Associated Biomarkers
| Biomarker |
|---|
| CD4+ T cell count (for HIV disease progression and treatment monitoring) |