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Target intelligence / Profile preview
CD4 T Lymphocyte (CD4)
- Target
- CD4
- Molecular classification
- Receptor, Cell surface glycoprotein
01
Overview
CD4 is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. It acts as a receptor and co-receptor in T cell signaling and plays a crucial role in immune responses. HIV exploits CD4 as its primary entry receptor to infect and destroy these cells, leading to immunodeficiency.
- Other names
- T-helper cellCD4+ T cellHelper T cell
02
Mechanism of action
Post-attachment inhibitor of HIV entry by blocking the interaction between virus-bound CD4 and chemokine co-receptors (CCR5/CXCR4).
03
Biological functions
Immune responseT cell activationAntigen recognitionCo-receptor for T cell receptor signaling
04
Disease associations
HIV infectionImmunodeficiencyAutoimmune diseases
05
Safety considerations
Potential for immune suppressionRisk of infusion-related reactions (for monoclonal antibody therapies like Ibalizumab)Need for careful monitoring of immune function
06
Interacting drugs
Ibalizumab
07
Biomarkers
CD4+ T cell count (for HIV disease progression and treatment monitoring)
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