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Target intelligence / Profile preview
CD44 molecule (Indian blood group) (CD44)
- Target
- CD44
- Molecular classification
- Receptor, Transmembrane glycoprotein, Cell surface adhesion receptor
01
Overview
CD44 is a multifunctional cell surface adhesion receptor involved in cell-cell interactions, cell adhesion to the extracellular matrix, and cell migration. It exists in multiple isoforms due to alternative splicing and plays a role in various physiological processes, including immune cell trafficking, hematopoiesis, and synaptic plasticity. Elevated expression is associated with cancer progression and inflammation, making it a potential therapeutic target.
- Other names
- P-glycoprotein 1HCELL
02
Mechanism of action
Modulation of cell adhesion and migration via ligand binding and intracellular signaling pathways.
03
Biological functions
Cell-cell interactionsCell adhesion to extracellular matrixMigrationLymphocyte activationHematopoiesisSynaptic plasticity
04
Disease associations
CancerInflammation
05
Safety considerations
Potential for off-target effects due to ubiquitous expressionComplex isoform diversity complicates therapeutic targeting
06
Biomarkers
Cancer progression markerCancer stem cell marker
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