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Target intelligence / Profile preview
CD46 Antigen (Membrane Cofactor Protein) (CD46)
- Target
- CD46
- Molecular classification
- Type I transmembrane glycoprotein, Complement regulatory protein
01
Overview
CD46, also known as Membrane Cofactor Protein (MCP), is a type I transmembrane glycoprotein that functions as a complement regulatory protein. It is ubiquitously expressed on most nucleated cells. The primary role of CD46 is to protect host cells from complement-mediated damage by acting as a cofactor for factor I–mediated cleavage of C3b and C4b, two key components of the complement system. It also modulates adaptive T helper type 1 (Th1) responses and functions as a co-stimulatory molecule during T cell activation.
- Other names
- MCPMIC10TRA2.10trophoblast-lymphocyte cross-reactive antigengp45-70
02
Mechanism of action
Cofactor for factor I–mediated cleavage of C3b and C4b
03
Biological functions
Complement regulationFactor I cofactor activityT cell co-stimulationImmune regulationSperm-oocyte fusion
04
Disease associations
Atypical hemolytic uremic syndrome (aHUS)Age-related macular degenerationAutoimmune diseases
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