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CD46 Protein (MCP)
- Target
- MCP
- Molecular classification
- Type I transmembrane glycoprotein, Complement control protein
01
Overview
CD46, also known as Membrane Cofactor Protein (MCP), is a type I transmembrane glycoprotein that functions as a key regulatory component of the complement system. It is expressed on nearly all nucleated cells (except erythrocytes) and acts as a cofactor for complement factor I-mediated cleavage/inactivation of C3b and C4b, protecting host cells from complement-mediated damage. It also serves as an entry receptor for several pathogens and plays a role in human reproduction and T cell activation. Overexpression is observed in various cancers making it a potential therapeutic target.
- Other names
- Membrane Cofactor ProteinCluster of Differentiation 46
02
Mechanism of action
Cofactor for complement factor I-mediated cleavage/inactivation of C3b and C4b
03
Biological functions
Complement regulationImmune response modulationSperm-oocyte fusionPathogen entry receptor
04
Disease associations
Atypical hemolytic uremic syndromeCancerInfectionInflammatory disorders
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