Molecular Classification
Type I transmembrane glycoprotein, Complement control protein
Other Names
Membrane Cofactor Protein, Cluster of Differentiation 46
Disease Roles
Atypical hemolytic uremic syndromeCancerInfection

CD46 Protein Overview

CD46, also known as Membrane Cofactor Protein (MCP), is a type I transmembrane glycoprotein that functions as a key regulatory component of the complement system. It is expressed on nearly all nucleated cells (except erythrocytes) and acts as a cofactor for complement factor I-mediated cleavage/inactivation of C3b and C4b, protecting host cells from complement-mediated damage. It also serves as an entry receptor for several pathogens and plays a role in human reproduction and T cell activation. Overexpression is observed in various cancers making it a potential therapeutic target.

Mechanism of Action

Cofactor for complement factor I-mediated cleavage/inactivation of C3b and C4b

Biological Functions

Complement regulation
Immune response modulation
Sperm-oocyte fusion
Pathogen entry receptor

Disease Associations

Atypical hemolytic uremic syndrome
Cancer
Infection
Inflammatory disorders

Safety Considerations

No safety concerns listed