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Target intelligence / Profile preview
CD52 Antigen (CD52)
- Target
- CD52
- Molecular classification
- Glycoprotein, Cell surface antigen
01
Overview
CD52, also known as CAMPATH-1 antigen, is a small, heavily glycosylated cell surface glycoprotein expressed on mature lymphocytes, monocytes, macrophages, eosinophils, dendritic cells, epithelial cells of the male reproductive tract, and spermatozoa. Its precise physiological role remains unclear, but proposed functions include antiadhesion, regulation of T-cell activation, and costimulation for regulatory T-cells. It is a therapeutic target for alemtuzumab, an anti-CD52 monoclonal antibody used in the treatment of B-cell malignancies, autoimmune diseases like multiple sclerosis, and potentially systemic mastocytosis.
- Other names
- CAMPATH-1 antigenHE5 antigen
02
Mechanism of action
Alemtuzumab induces complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity, leading to lymphocyte depletion.
03
Biological functions
AntiadhesionRegulation of T-cell activationCostimulation for regulatory T-cellsLymphocyte transendothelial migrationFertilization processes
04
Disease associations
B-cell malignanciesChronic Lymphocytic LeukemiaAutoimmune diseasesMultiple SclerosisSystemic Mastocytosis
05
Interacting drugs
Alemtuzumab (CAMPATH)
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