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Target intelligence / Profile preview
CD7 antigen (CD7)
- Target
- CD7
- Molecular classification
- Immunoglobulin superfamily, Transmembrane glycoprotein
01
Overview
CD7 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed on thymocytes, mature T lymphocytes, NK cells, and a subset of pre-B lymphocytes. CD7 plays a crucial role in T-cell interactions, early lymphoid development, and costimulatory signaling during T-cell activation. It serves as an immunohistochemical marker for T-lineage malignancies and aberrant expression patterns are associated with specific myeloid disorders and cutaneous T-cell lymphomas. CD7 is also being explored as a target for CAR-T cell therapy in aggressive leukemias.
- Other names
- GP40LEU-9TP41Tp40CD7 molecule
02
Mechanism of action
Chimeric antigen receptor (CAR) therapies targeting CD7
03
Biological functions
T-cell activationCostimulationRegulation of cytokine productionEarly lymphoid development
04
Disease associations
Acute lymphoblastic leukemia/lymphoma (T-lineage)Refractory anemia with excess blasts (RAEB)Mycosis fungoidesSezary syndromeSezary leukemiaHTLV-I+ adult T-cell leukemia/lymphoma
05
Safety considerations
Potential for on-target, off-tumor toxicity in CAR-T cell therapy
06
Biomarkers
CD7 expression levels in leukemia/lymphoma cellsLoss of CD7 expression in cutaneous T-cell lymphoma
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