CD8-positive T Cell (CTL)

CD8-positive T cells, also known as cytotoxic T lymphocytes (CTLs), are a subset of T cells critical for cell-mediated immunity. They recognize and eliminate infected or malignant cells through direct cytotoxicity and cytokine secretion. Their function is essential for defense against intracellular pathogens and tumors, but dysregulation can lead to autoimmune diseases or other immune-related disorders.

Other names

Cytotoxic T LymphocyteCD8+ T cellCD8 T cell

CD8+ T cells recognize and kill infected or malignant cells by releasing cytotoxic granules containing perforin and granzymes, or by inducing apoptosis through Fas-FasL interaction. They also secrete cytokines like IFN-gamma and TNF-alpha to modulate the immune response.