CDC-like kinase 4 (CLK4)

Molecular Classification

Enzyme, Dual specificity kinase, Protein kinase

Disease Roles

Fanconi Anemia, Complementation Group ANoonan Syndrome 1Cardiac hypertrophy

CDC-like kinase 4 Overview

CLK4 is a member of the CDC2-like protein kinase (CLK) family, which are dual specificity kinases capable of phosphorylating both serine/threonine and tyrosine residues. This protein plays a role in the regulation of RNA splicing by phosphorylating serine- and arginine-rich (SR) proteins. Recent studies have linked CLK4 to the regulation of cardiac hypertrophy through phosphorylation of nexilin (NEXN), suggesting it as a potential therapeutic target for heart failure.

Mechanism of Action

Inhibition of CLK4 kinase activity to modulate SR protein phosphorylation and RNA splicing; modulation of NEXN phosphorylation.

Biological Functions

Regulation of RNA splicing

Phosphorylation of SR proteins

Regulation of cardiac hypertrophy

Disease Associations

Fanconi Anemia, Complementation Group A

Noonan Syndrome 1

Cardiac hypertrophy

Heart failure

Safety Considerations

No safety concerns listed