CDP-diacylglycerol synthase 2 mRNA 3'-untranslated region (CDS2 mRNA 3'-UTR)

The CDS2 mRNA 3'-untranslated region (3'-UTR) is a critical regulatory segment of the messenger RNA encoding CDP-diacylglycerol synthase 2, an enzyme essential for the phosphoinositide cycle. This region contains binding sites for various regulatory molecules, most notably microRNAs such as miR-125b, which post-transcriptionally regulate CDS2 expression levels (PubMed: 24631211). CDS2 itself catalyzes the conversion of phosphatidic acid to CDP-diacylglycerol, a precursor for phosphatidylinositol, which is vital for VEGFA-mediated signaling and angiogenesis (PubMed: 25103571). In many cancers, CDS2 is upregulated to support rapid cell proliferation and tumor-induced blood vessel formation, making its mRNA 3'-UTR an attractive target for therapeutic intervention. By targeting this region with microRNA mimics or antisense oligonucleotides, researchers aim to downregulate CDS2 protein production, thereby inhibiting tumor growth and pathological angiogenesis (PubMed: 30217930). Consequently, the CDS2 mRNA 3'-UTR serves as a focal point for developing precision medicines that modulate lipid metabolism and signaling pathways in oncology.

Other names

CDP-diglyceride pyrophosphorylase 2 mRNA 3'-UTRCDP-diglyceride synthase 2 mRNA 3'-UTRCDS2 3'-UTR

MicroRNA-mediated translational repression or mRNA degradation; Antisense oligonucleotide-mediated knockdown of protein expression.