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Target intelligence / Profile preview
Cell Division Cycle 37, HSP90 Cochaperone (CDC37) (CDC37)
- Target
- CDC37
- Molecular classification
- Molecular Chaperone, HSP90 Co-chaperone
01
Overview
CDC37 is a molecular chaperone that plays a crucial role in cell signal transduction by forming complexes with Hsp90 and numerous protein kinases. It is essential for directing Hsp90 to its target kinases, thereby stabilizing and promoting their activity. CDC37 is involved in various signaling pathways and has been genetically linked with the activity of several oncogenic kinases. Given its role in maintaining the activity of these kinases, it could be a therapeutic target for diseases involving aberrant kinase activity.
- Other names
- CDC37Cell Division Control Protein 37 HomologHSP90 Cochaperone
02
Mechanism of action
Facilitates the interaction between Hsp90 and various kinases, stabilizing and promoting their activity
03
Biological functions
Signal transductionCell cycle regulationChaperone activity
04
Disease associations
Cancerpossibly involved in other diseases like ectodermal dysplasias
05
Safety considerations
Potential for affecting multiple signaling pathways, possibly leading to off-target effects
06
Interacting drugs
Hsp90 inhibitors (indirect interaction)
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