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Target intelligence / Profile preview
Cell division cycle 7-related protein kinase (CDC7) (CDC7)
- Target
- CDC7
- Molecular classification
- Enzyme, Protein kinase, Serine/threonine kinase
01
Overview
Cell division cycle 7-related protein kinase (CDC7) is a serine/threonine kinase localized to the nucleus that plays a critical role in initiating DNA replication during the cell cycle. CDC7 functions as a key regulator of the G1/S phase transition by phosphorylating essential substrates including MCM proteins and CLASPIN, thereby controlling the initiation of DNA synthesis. As a fundamental component of replication control, CDC7 represents a therapeutic target for cancer treatment, with multiple investigational inhibitors and modulators currently in development, including compounds such as Simurosertib, PHA-767491, and BMS-863233. The kinase's essential role in DNA replication makes it particularly relevant for targeting rapidly dividing cancer cells.
- Other names
- CDC7-related kinaseCDC7L1HsCdc7huCdc7
02
Mechanism of action
Inhibitor and modulator
03
Biological functions
Initiation of DNA replicationKinase activity involved in cell cycle regulationPhosphorylation of critical substrates regulating the G1/S phase transitionATP bindingPhosphorylation of MCM proteinsPhosphorylation of CLASPIN
04
Disease associations
Cancer
05
Interacting drugs
(7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one (experimental)
3 more in the full profile.
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