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Cell Membrane Lipid Peroxidation
- Molecular classification
- Process, Oxidative damage
01
Overview
Cell membrane lipid peroxidation refers to the oxidative degradation of lipids, particularly polyunsaturated fatty acids (PUFAs), within cell membranes. This process is initiated when reactive oxygen species (ROS) or free radicals attack these lipids, leading to the formation of lipid radicals and subsequently lipid peroxides or other oxidation products. The process is a major mechanism underlying oxidative damage to cell structures and can result in increased membrane permeability, disruption of cellular integrity, and ultimately cell death.
- Other names
- Lipid peroxidationMembrane lipid peroxidationOxidative degradation of membrane lipids
02
Mechanism of action
Antioxidants neutralize free radicals, inhibiting the propagation of lipid peroxidation.
03
Biological functions
Oxidative degradation of membrane lipidsMediation of oxidative stressAlteration of membrane permeabilityInduction of cell deathSignaling molecule production
04
Disease associations
AgingNeurodegenerative diseasesCardiovascular disordersCancerOxidative stress-related pathologies
05
Safety considerations
Excessive lipid peroxidation can lead to cell damage and death.Secondary products like MDA and 4-HNE can be cytotoxic at high concentrations.Uncontrolled lipid oxidation can contribute to various diseases.
06
Interacting drugs
Vitamin E
2 more in the full profile.
07
Biomarkers
Malondialdehyde (MDA)4-Hydroxynonenal (4-HNE)Conjugated dienesLipid hydroperoxides (LOOH)
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