Gosset Molecular Classification
Process, Oxidative damage
Other Names
Lipid peroxidation, Membrane lipid peroxidation, Oxidative degradation of membrane lipids
Disease Roles
Cell Membrane Lipid Peroxidation Overview
Cell membrane lipid peroxidation refers to the oxidative degradation of lipids, particularly polyunsaturated fatty acids (PUFAs), within cell membranes. This process is initiated when reactive oxygen species (ROS) or free radicals attack these lipids, leading to the formation of lipid radicals and subsequently lipid peroxides or other oxidation products. The process is a major mechanism underlying oxidative damage to cell structures and can result in increased membrane permeability, disruption of cellular integrity, and ultimately cell death.
Mechanism of Action
Antioxidants neutralize free radicals, inhibiting the propagation of lipid peroxidation.
Biological Functions
Oxidative degradation of membrane lipids
Mediation of oxidative stress
Alteration of membrane permeability
Induction of cell death
Signaling molecule production
Disease Associations
Aging
Neurodegenerative diseases
Cardiovascular disorders
Cancer
Oxidative stress-related pathologies
Safety Considerations
- Excessive lipid peroxidation can lead to cell damage and death.
- Secondary products like MDA and 4-HNE can be cytotoxic at high concentrations.
- Uncontrolled lipid oxidation can contribute to various diseases.
Interacting Drugs
Vitamin E
Vitamin C
Antioxidants
Associated Biomarkers
| Biomarker |
|---|
| Malondialdehyde (MDA) |
| 4-Hydroxynonenal (4-HNE) |
| Conjugated dienes |
| Lipid hydroperoxides (LOOH) |