Cell proliferation-associated gene (null; not a specific molecule or standard target name) (null)

Cell proliferation genes are a diverse group of genes that orchestrate the complex process of cell division and growth by regulating the cell cycle, DNA replication, and associated signaling pathways[2][7]. They comprise various molecular classes, including cyclins (e.g., CCND1), cyclin-dependent kinases (e.g., CDK4/6), DNA replication enzymes (e.g., TOP2A), checkpoint regulators (e.g., MAD2L1), transcription factors (e.g., MYBL2), and cell cycle markers (e.g., MKI67)[7]. Dysregulation of cell proliferation genes commonly underlies diseases characterized by abnormal growth, most notably cancer, making these genes important targets for cancer therapies and prognostic biomarkers[1][2][7]. However, due to their fundamental roles in normal cell division, therapies targeting these pathways frequently cause side effects in non-malignant tissues undergoing proliferation, posing significant clinical safety challenges[2][7]. Summary: "Cell proliferation genes" is not a correct or sufficiently specific entry for a molecular therapeutic target; it refers to an entire group of molecular entities involved in cell cycle and cell growth, rather than a defined target suitable for structured pharmacological databases. For any specific target, a gene name (e.g., "Cyclin-dependent kinase 4") or protein (e.g., "Ki-67 antigen") should be used instead.

Other names

proliferation marker genescell growth genescell cycle-regulatory genes

Inhibition of cell cycle-related kinases (e.g., CDK4/6 inhibition); Blockade of DNA replication; Induction of cell cycle arrest (G1/S, G2/M) or apoptosis.