Cell Surface Antigen (CSA)

Cell Surface Antigen Overview

Cell surface antigens are molecules present on the exterior of cells that serve as markers for cell identification, communication, and immune recognition. These antigens can be proteins, glycoproteins, or glycolipids embedded in or attached to the plasma membrane. They play critical roles in cellular adhesion, antigen recognition by the immune system, and as receptors for soluble mediators. Abnormal expression patterns are often associated with diseases such as cancer, making them therapeutic targets. In antibody-drug conjugate (ADC) therapy for cancer treatment, ideal target antigens should be highly expressed on tumor cells but minimally present on healthy tissues to maximize efficacy while minimizing toxicity.

Mechanism of Action

Antibody binding, receptor inhibition, targeted drug delivery

Biological Functions

Safety Considerations

Interacting Drugs

Associated Biomarkers