Cell surface glycoprotein CD200 receptor 1 (CD200R1) (CD200R1)

Cell surface glycoprotein CD200 receptor 1 (CD200R1) is an inhibitory receptor primarily expressed on myeloid cells, including macrophages, mast cells, and neutrophils, as well as certain T-cell subsets (UniProt Q9ES57). It belongs to the immunoglobulin superfamily and is characterized by its interaction with the ligand CD200 (OX-2), which is widely expressed on various cell types. In mice, the CD200-CD200R1 interaction is a critical regulator of immune homeostasis; signaling through the receptor's cytoplasmic NPxY motif recruits Dok1 and Dok2, leading to the inhibition of pro-inflammatory MAPK and NF-kappaB pathways (Wright et al., 2003, Journal of Immunology). This axis plays a significant role in cancer, where tumor cells may overexpress CD200 to suppress myeloid-mediated anti-tumor responses, and in inflammatory diseases where the pathway is underactive (Hoek et al., 2000, Science). Therapeutic strategies targeting mouse CD200R1 include the use of agonistic fusion proteins to treat autoimmune disorders and antagonistic antibodies to enhance vaccine efficacy or tumor clearance in preclinical models (Gorczynski, 2005, Expert Opinion on Therapeutic Targets). Understanding this receptor is vital for developing immunotherapies that modulate the myeloid compartment of the immune system.

Other names

CD200 receptor 1OX-2 receptorCD200RMox2rCrv1

Agonism of CD200R1 delivers inhibitory signals to myeloid cells to suppress inflammation, while antagonism of the receptor-ligand interaction enhances immune responses.