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Target intelligence / Profile preview
Cellular DNA (via platinum-DNA adducts) (Pt-DNA adducts)
- Target
- Pt-DNA adducts
- Molecular classification
- DNA, DNA adduct
01
Overview
Cellular DNA, when modified by platinum-based chemotherapeutic agents, forms platinum-DNA adducts. These adducts interfere with DNA replication and transcription, leading to apoptosis, especially in rapidly dividing cancer cells. The level and persistence of these adducts are critical determinants of drug sensitivity and resistance.
- Other names
- Platinum-DNA adductsPt-DNA crosslinksCisplatin-DNA adductsCarboplatin-DNA adductsOxaliplatin-DNA adducts
02
Mechanism of action
Covalent binding to DNA, forming adducts that disrupt replication and transcription, leading to cell death.
03
Biological functions
DNA replication inhibitionTranscription inhibitionApoptosis inductionCell death
04
Disease associations
Cancer
05
Safety considerations
MyelosuppressionLeukopeniaResistance developmentToxicity
06
Interacting drugs
Cisplatin
2 more in the full profile.
07
Biomarkers
Pt-DNA adduct levelsERCC1 expression
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