Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cellular Senescence Pathway
- Molecular classification
- Signaling Pathway, Cell Cycle Regulation, Tumor Suppressor Pathway
01
Overview
The cellular senescence pathway is a biological process leading to a stable cell cycle arrest, triggered by various stressors. It involves the p53/p21 and p16/Rb pathways, resulting in characteristic phenotypic changes and the secretion of the Senescence-Associated Secretory Phenotype (SASP). While initially beneficial for tumor suppression and tissue repair, chronic activation contributes to aging-related pathologies.
- Other names
- Cellular Aging PathwaySenescence Pathway
02
Mechanism of action
Senolytics selectively eliminate senescent cells by targeting their survival pathways.
03
Biological functions
Cell cycle arrestTumor suppressionTissue remodelingInflammationDNA damage response
04
Disease associations
CancerAgingAge-related diseasesInflammagingWound healing
05
Safety considerations
Potential side effects due to overlap with normal cell survival mechanismsComplex therapeutic target requiring precise modulation
06
Interacting drugs
Senolytics
1 more in the full profile.
07
Biomarkers
Senescence-associated β-galactosidase activityp16^INK4ASenescence-associated heterochromatin foci (SAHF)DNA-SCARS
Beyond the preview
Go deeper on Cellular Senescence Pathway.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cellular Senescence Pathway.