Central Nervous System Depression (None)

Central Nervous System Depression Overview

Central nervous system (CNS) depression is a physiological state in which the activity of the brain and spinal cord—the core components of the CNS—is significantly slowed. This can result in decreased heart rate, reduced breathing rate, impaired consciousness, and in severe cases, coma or death. It is often caused by misuse or overdose of CNS depressant drugs, which enhance the effect of GABA, an inhibitory neurotransmitter. Medical conditions and recreational drug use can also contribute. Excessive CNS depression can be fatal.

Mechanism of Action

Enhancement of GABAergic neurotransmission, reduction of neuronal excitability.

Biological Functions

Safety Considerations

Interacting Drugs