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Target intelligence / Profile preview
Centriole, cilia and spindle-associated protein (CCSAP)
- Target
- CCSAP
- Molecular classification
- Other (Microtubule-associated protein)
01
Overview
Centriole, cilia and spindle-associated protein (CCSAP), also known as CSAP or C1orf96, is a microtubule-binding protein that is essential for microtubule stabilization and regulation of mitotic spindle assembly. CCSAP localizes to centrosomes, the spindle, ciliary transition zones, and the cytoskeleton. It binds to polyglutamylated tubulin, promoting the stability and organization of microtubules during mitosis, thus ensuring proper bipolar spindle formation and maintenance. CCSAP is vital for normal cell division and embryonic development, and is required for proper cilia beating. Its aberrant regulation has been associated with developmental brain defects and with altered drug responses in certain cancers[1][2][3]. No approved drugs target CCSAP, and it is not currently considered a direct therapeutic target or established biomarker.
- Other names
- CSAPC1orf96FLJ41471centriole and spindle-associated protein
02
Mechanism of action
Not applicable (no known drugs acting directly on CCSAP reported)
03
Biological functions
Microtubule bindingMicrotubule stabilizationRegulation of mitotic spindle assemblyInhibition of microtubule depolymerizationRequired for cilia beatingInvolved in proper embryonic and brain development
04
Disease associations
Cancer (implicated in drug resistance mechanisms, especially paclitaxel resistance in triple negative breast cancer)Developmental defects (notably in brain development)Other (Mononeuropathy of the median nerve, Median rhomboid glossitis)
05
Safety considerations
No direct therapeutic safety concerns described (as not a therapeutic target)
06
Interacting drugs
None known or reported
07
Biomarkers
None established for clinical use
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