Ceramide AP (Ceramide AP)

Ceramide AP Overview

Ceramide AP is a specific type of ceramide lipid found in the human epidermis and used widely in cosmetic formulations for its role in maintaining and restoring the skin’s protective barrier. Chemically known as N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine or phytosphingosine-based ceramide with an α-hydroxy fatty acid chain (hence "AP"), it is also referred to as Ceramide 6 II or Biomide 6 among other synonyms[1][2][5]. Ceramides are essential sphingolipids that act as structural “mortar” between skin cells in the stratum corneum. They help organize intercellular lipids into ordered layers that prevent moisture loss and block environmental threats. The unique structure of Ceramide AP provides superior integrity to the skin barrier compared to some other ceramides; it is particularly effective for repairing damaged or compromised skin barriers by reducing transepidermal water loss and enhancing resilience against irritants[8]. While ceramides broadly participate in cell signaling related to apoptosis and inflammation within cells[3], Ceramide AP itself is not considered a therapeutic target such as a receptor or enzyme but rather a bioactive lipid ingredient primarily used for topical application in skincare products. It does not have known direct drug interactions nor established mechanisms of action relevant to pharmacology beyond its physical–chemical effects on the epidermal barrier. Because "Ceramide AP" refers specifically to a lipid molecule rather than a protein target (receptor/enzyme/transporter), it should not be classified as a therapeutic target per se; thus **is_target** should be set to false and **is_incorrect** set to true if searching for classical drug targets like receptors or enzymes[5][8].

Mechanism of Action

Biological Functions

Safety Considerations