Molecular Classification
Epithelial Tissue
Other Names
Columnar Epithelium, Endocervical Epithelium
Disease Roles
Cervical cancerHPV infection

Cervical Glandular Epithelium Overview

The cervical glandular epithelium, also known as the columnar or endocervical epithelium, is a specialized epithelial tissue lining the endocervical canal of the uterine cervix. It consists of a single layer of tall, columnar cells with dark-staining nuclei located near the basement membrane. It secretes mucus and other fluids that play roles in fertility by facilitating sperm passage and providing protection against pathogens. The transformation zone—where glandular meets squamous epithelium—is clinically significant as it is prone to metaplasia and neoplastic transformation.

Mechanism of Action

Biological Functions

Mucus secretion
Sperm passage facilitation
Pathogen protection
Physical barrier
Immunological barrier

Disease Associations

Cervical cancer
HPV infection

Safety Considerations

  • Transformation zone prone to metaplasia and neoplastic transformation