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Target intelligence / Profile preview
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A)
- Target
- PDE3A
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A) is an enzyme that hydrolyzes cAMP and cGMP, regulating their intracellular concentrations. It plays critical roles in cardiovascular function, platelet aggregation, smooth muscle contraction/relaxation, oocyte maturation, and lipid metabolism. PDE3A activity is regulated by phosphorylation and cGMP binding. Dysregulation or mutation is linked to hypertension, heart failure, diabetes, pulmonary hypertension, and cancer, making it a potential therapeutic target.
- Other names
- Cyclic GMP-inhibited phosphodiesterase ACGI-PDE AcGI-PDEcGMP-inhibited cAMP phosphodiesterase
02
Mechanism of action
Inhibition of PDE3A increases intracellular cAMP and/or cGMP levels.
03
Biological functions
Hydrolysis of cAMP to AMPRegulation of myocardial contractilityBlood coagulationVascular permeability regulationOocyte maturation and developmentNegative regulation of apoptosis
04
Disease associations
HypertensionHeart failureDiabetesPulmonary HypertensionCancer
05
Safety considerations
Potential cardiovascular side effects due to effects on cardiac contractility.
06
Interacting drugs
Enoximone
2 more in the full profile.
07
Biomarkers
PDE3A expression levels as a predictor of sensitivity to cancer therapeutics (e.g., Zardaverine)
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